Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immunodeficiency.

نویسندگان

  • Tomoki Kawai
  • Ryuta Nishikomori
  • Kazushi Izawa
  • Yuuki Murata
  • Naoko Tanaka
  • Hidemasa Sakai
  • Megumu Saito
  • Takahiro Yasumi
  • Yuki Takaoka
  • Tatsutoshi Nakahata
  • Tomoyuki Mizukami
  • Hiroyuki Nunoi
  • Yuki Kiyohara
  • Atsushi Yoden
  • Takuji Murata
  • Shinya Sasaki
  • Etsuro Ito
  • Hiroshi Akutagawa
  • Toshinao Kawai
  • Chihaya Imai
  • Satoshi Okada
  • Masao Kobayashi
  • Toshio Heike
چکیده

Somatic mosaicism has been described in several primary immunodeficiency diseases and causes modified phenotypes in affected patients. X-linked anhidrotic ectodermal dysplasia with immunodeficiency (XL-EDA-ID) is caused by hypomorphic mutations in the NF-κB essential modulator (NEMO) gene and manifests clinically in various ways. We have previously reported a case of XL-EDA-ID with somatic mosaicism caused by a duplication mutation of the NEMO gene, but the frequency of somatic mosaicism of NEMO and its clinical impact on XL-EDA-ID is not fully understood. In this study, somatic mosaicism of NEMO was evaluated in XL-EDA-ID patients in Japan. Cells expressing wild-type NEMO, most of which were derived from the T-cell lineage, were detected in 9 of 10 XL-EDA-ID patients. These data indicate that the frequency of somatic mosaicism of NEMO is high in XL-ED-ID patients and that the presence of somatic mosaicism of NEMO could have an impact on the diagnosis and treatment of XL-ED-ID patients.

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X-linked ectodermal dysplasia and immunodeficiency caused by reversion mosaicism of NEMO reveals a critical role for NEMO in human T-cell development and/or survival.

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عنوان ژورنال:
  • Blood

دوره 119 23  شماره 

صفحات  -

تاریخ انتشار 2012